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1

The Role of Oxidized LDL in Atherogenesis: Immunological Response and Anti-phospholipid Antibodies

JOSEPH L. WITZTUM, SOHVI HÖRKKÖ

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 705 KB

english, 1997

2

Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)

Silaste, M.-L., Rantala, M., Alfthan, G., Aro, A., Witztum, J. L., Kesaniemi, Y. A., Horkko, S.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2004

Language:

english

File:

PDF, 521 KB

english, 2004

3

Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation

Silaste, Marja-Leena, Alfthan, Georg, Aro, Antti, Antero Kesäniemi, Y., Hörkkö, Sohvi

Journal:

British Journal Of Nutrition

Year:

2007

Language:

english

File:

PDF, 287 KB

english, 2007

4

Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations

Johan Frostegård, Elisabet Svenungsson, Ruihua Wu, Iva Gunnarsson, Ingrid E. Lundberg, Lars Klareskog, Sohvi Hörkkö, Joseph L. Witztum

Journal:

Arthritis & Rheumatism

Year:

2005

Language:

english

File:

PDF, 96 KB

english, 2005

5

Thyroid hormone receptor β1 in normal colon and colorectal cancer–association with differentiation, polypoid growth type and K-ras mutations

Tuomo T. Hörkkö, Karoliina Tuppurainen, Susannah M. George, Petra Jernvall, Tuomo J. Karttunen, Markus J. Mäkinen

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 398 KB

english, 2006

6

Mechanisation of rock bolting : World Min, V33, N9, Aug 1980, P54–55

Journal:

International Journal of Rock Mechanics and Mining Sciences & Geomechanics Abstracts

Year:

1981

Language:

english

File:

PDF, 72 KB

english, 1981

7

The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes

S. M. Pöykkö, O. Ukkola, H. Kauma, E. Kellokoski, S. Hörkkö, Y. A. Kesäniemi

Journal:

Year:

2005

Language:

english

File:

PDF, 201 KB

english, 2005

8

Early atherosclerosis and IgG2 to bacteria are associated with FcγRIIa genotype in non-smokers

M. Sämpi, O. Ukkola, M. Päivänsalo, Y. A. Kesäniemi, S. Hörkkö

Journal:

European Journal of Clinical Investigation

Year:

2009

Language:

english

File:

PDF, 457 KB

english, 2009

9

Plasma ghrelin concentrations are positively associated with carotid artery atherosclerosis in males

S. M. PÖYKKÖ, E. KELLOKOSKI, O. UKKOLA, H. KAUMA, M. PÄIVÄNSALO, Y. A. KESÄNIEMI, S. HÖRKKÖ

Journal:

Journal of Internal Medicine

Year:

2006

Language:

english

File:

PDF, 125 KB

english, 2006

10

Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis

Antti E. Nissinen, L. Maria Laitinen, Sakari Kakko, Anders Helander, Markku J. Savolainen, Sohvi Hörkkö

Journal:

Addiction Biology

Year:

2012

Language:

english

File:

PDF, 454 KB

english, 2012

11

Immunological Detection of in Vitro Formed Phosphatidylethanol—An Alcohol Biomarker—With Monoclonal Antibodies

Antti E. Nissinen, Sanna M. Mäkelä, Jussi T. Vuoristo, Marja K. Liisanantti, Minna L. Hannuksela, Sohvi Hörkkö, Markku J. Savolainen

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2008

Language:

english

File:

PDF, 453 KB

english, 2008

12

Effects of the antioxidant Pycnogenol® on cellular redox systems in U1285 human lung carcinoma cells

Valentina Gandin, Christina Nyström, Anna-Klara Rundlöf, Kerstin Jönsson-Videsäter, Frank Schönlau, Jarmo Hörkkö, Mikael Björnstedt, Aristi P. Fernandes

Journal:

Year:

2009

Language:

english

File:

PDF, 370 KB

english, 2009

13

Scavenger Receptors, Oxidized LDL, and Atherosclerosis

AGNES BOULLIER, DAVID A. BIRD, MI-KYUNG CHANG, EDWARD A. DENNIS, PETER FRIEDMAN, KRISTIN GILLOTTE-TAYLOR, SOHVI HÖRKKÖ, WULF PALINSKI, OSWALD QUEHENBERGER, PETER SHAW, DANIEL STEINBERG, VALESKA TERPST

Journal:

Annals of the New York Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 2.35 MB

english, 2001

14

Carbamylation-induced alterations in low-density lipoprotein metabolism

Hörkkö, Sohvi, Savolainen, Markku J, Kervinen, Kari, Kesäniemi, Y Antero

Journal:

Kidney International

Year:

1992

Language:

english

File:

PDF, 664 KB

english, 1992

15

Decreased clearance of low-density lipoprotein in patients with chronic renal failure

Hörkkö, Sohvi, Huttunen, Kaisa, Korhonen, Taina, Kesäniemi, Y Antero

Journal:

Kidney International

Year:

1994

Language:

english

File:

PDF, 887 KB

english, 1994

16

Decreased clearance of low-density lipoprotein in uremic patients under dialysis treatment

Hörkkö, Sohvi, Huttunen, Kaisa, Kesäniemi, Y Antero

Journal:

Kidney International

Year:

1995

Language:

english

File:

PDF, 919 KB

english, 1995

17

Protein carbamylation links inflammation, smoking, uremia and atherogenesis

Nicholls, Stephen J, Rodriguez, E Rene, Kummu, Outi, Hörkkö, Sohvi, Barnard, John, Reynolds, Wanda F, Topol, Eric J, DiDonato, Joseph A, Hazen, Stanley L, Wang, Zeneng

Journal:

Nature Medicine

Year:

2007

Language:

english

File:

PDF, 438 KB

english, 2007

18

Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL

Binder, Christoph J, Hörkkö, Sohvi, Dewan, Asheesh, Chang, Mi-Kyung, Kieu, Emily P, Goodyear, Carl S, Shaw, Peter X, Palinski, Wulf, Witztum, Joseph L, Silverman, Gregg J

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 552 KB

english, 2003

19

Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a

Marja Veneskoski, S. Pauliina Turunen, Outi Kummu, Antti Nissinen, Sirpa Rannikko, Anna-Liisa Levonen, Sohvi Hörkkö

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

20

Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease

Jari Kankaanpää, S. Pauliina Turunen, Virpi Moilanen, Sohvi Hörkkö, Anne M. Remes

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 441 KB

english, 2009

21

DIETARY CAROTENOIDS REDUCE PLASMA TOTAL AND LDL CHOLESTEROL CONCENTRATIONS AND LDL OXIDATION

M-L. Silaste, G. Alfthan, A. Aro, Y.A. Kesaniemi, S. Horkko

Journal:

Journal of the American Dietetic Association

Year:

2003

Language:

english

File:

PDF, 48 KB

english, 2003

22

Immunological responses to oxidized LDL

Sohvi Hörkkö, Christoph J Binder, Peter X Shaw, Mi-Kyung Chang, Gregg Silverman, Wulf Palinski, Joseph L Witztum

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 89 KB

english, 2000

23

Decreased clearance of uraemic and mildly carbamylated low-density lipoprotein

S. HÖRKKÖ, K. HUTTUNEN, K. KERVINEN, Y. ANTERO KESÄNIEMI

Journal:

European Journal of Clinical Investigation

Year:

1994

Language:

english

File:

PDF, 813 KB

english, 1994

24

Budding invasive margin and prognosis in colorectal cancer – no direct association with β-catenin expression

Tuomo T. Hörkkö, Kai Klintrup, Johanna M. Mäkinen, Juha B. Näpänkangas, Hannu J. Tuominen, Jyrki Mäkelä, Tuomo J. Karttunen, Markus J. Mäkinen

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 315 KB

english, 2006

25

Ghrelin vaccination decreases plasma MCP-1 level in LDLR−/−-mice

Eija Kellokoski, Outi kummu, Raisa Serpi, Petri Lehenkari, Olavi ukkola, Y. Antero Kesäniemi, Sohvi Hörkkö

Journal:

Year:

2009

Language:

english

File:

PDF, 525 KB

english, 2009

26

W12-P-018 Lipid-peroxidation is enhanced in SLE patients and associated with arterial and renal disease manifestations

Frostegard, J., Svenungsson, E., Wu, R., Gunnarsson, I., Lundberg, I., Klareskog, L., Hörkkö, S., Witztum, J.

Journal:

Atherosclerosis Supplements

Year:

2005

Language:

english

File:

PDF, 272 KB

english, 2005

27

PO9-242 PRESENCE OF IGG ANTIBODIES TO CARBAMYLATED PROTEINS ARE RELATED TO ANTIBODIES BINDING TO APOPTOTIC CELLS

Kummu, O., Ruskoaho, H., Kesaniemi, Y.A., Horkko, S.

Journal:

Atherosclerosis Supplements

Year:

2007

Language:

english

File:

PDF, 94 KB

english, 2007

28

PO19-519 PLASMA IL-5 LEVELS ARE ASSOCIATED WITH ANTIBODIES TO OXIDIZED LDL AND SUBCLINICAL ATHEROSCLEROSIS IN HUMANS

Sampi, M., Ukkola, O., Paivansalo, M., Ruskoaho, H., Kesaniemi, Y.A., Horkko, S.

Journal:

Atherosclerosis Supplements

Year:

2007

Language:

english

File:

PDF, 95 KB

english, 2007

29

PO22-703 EFFECTS OF GHRELIN VACCINATION IN MICE

Kellokoski, E., Ruskoaho, H., Kesaniemi, Y.A., Horkko, S.

Journal:

Atherosclerosis Supplements

Year:

2007

Language:

english

File:

PDF, 68 KB

english, 2007

30

EFFECTS OF GHRELIN IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS AND BINDING OF OXIDIZED LDL ON MACROPHAGES

Kellokoski, E., Kunnari, A., Jokela, M., Kesaniemi, Y., Horkko, S.

Journal:

Atherosclerosis Supplements

Year:

2008

Language:

english

File:

PDF, 66 KB

english, 2008

31

Ghrelin and obestatin modulate early atherogenic processes on cells: enhancement of monocyte adhesion and oxidized low-density lipoprotein binding

Eija Kellokoski, Anne Kunnari, Maarit Jokela, Sanna Mäkelä, Y. Antero Kesäniemi, Sohvi Hörkkö

Journal:

Year:

2009

Language:

english

File:

PDF, 309 KB

english, 2009

32

Plasma Interleukin-5 Levels Are Related to Antibodies Binding to Oxidized Low-Density Lipoprotein and to Decreased Subclinical Atherosclerosis

Maritta Sämpi, Olavi Ukkola, Markku Päivänsalo, Y. Antero Kesäniemi, Christoph J. Binder, Sohvi Hörkkö

Journal:

Journal of the American College of Cardiology

Year:

2008

Language:

english

File:

PDF, 266 KB

english, 2008

33

Biological significance of autoantibodies to oxidative neoepitopes

W. Palinski, S. Hörkkö, P. Shaw, S. Tsimikas, G. Silverman, J.L. Witztum

Journal:

Atherosclerosis

Year:

2000

Language:

english

File:

PDF, 186 KB

english, 2000

34

The modulation of protein synthesis by T3 in Caco-2 colorectal cancer cells – the role of nuclear targeting of TR receptors

T. Kantola, K. Tuppurainen, T. Hörkkö, T.J. Karttunen, S. Eskelinen, M.J. Mäkinen

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 89 KB

english, 2008

35

The absence of macrophage Nrf2 promotes early atherogenesis

Ruotsalainen, A.-K., Inkala, M., Partanen, M. E., Lappalainen, J. P., Kansanen, E., Makinen, P. I., Heinonen, S. E., Laitinen, H. M., Heikkila, J., Vatanen, T., Horkko, S., Yamamoto, M., Yla-Herttuala

Journal:

Cardiovascular Research

Year:

2013

Language:

english

File:

PDF, 608 KB

english, 2013

36

HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction

Rahtu-Korpela, L., Karsikas, S., Horkko, S., Blanco Sequeiros, R., Lammentausta, E., Makela, K. A., Herzig, K.-H., Walkinshaw, G., Kivirikko, K. I., Myllyharju, J., Serpi, R., Koivunen, P.

Journal:

Year:

2014

Language:

english

File:

PDF, 4.02 MB

english, 2014

37

Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes

Poykko, S. M., Kellokoski, E., Horkko, S., Kauma, H., Kesaniemi, Y. A., Ukkola, O.

Journal:

Year:

2003

Language:

english

File:

PDF, 126 KB

english, 2003

38

Th-W46:1 Oxidation of LDL leads its recognition by multiple arcs of innate immunity

Binder, C.J., Chang, M.K., Boullier, A., Chou, M.Y., Shaw, P.X., Hartvigsen, K., Hansen, L., Woelkers, D.A., Miller, Y.I., Hörkkö, S., Witztum, J.L.

Journal:

Atherosclerosis Supplements

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

39

Modification of VLDL apoprotein B by acetaldehyde alters apoprotein B metabolism

Kervinen, Kari, Hörkkö, Sohvi, Beltz, William F., Antero Kesaniemi, Y.

Journal:

Year:

1995

Language:

english

File:

PDF, 615 KB

english, 1995

40

The Epitopes for Some Antiphospholipid Antibodies are Adducts of Oxidized Phospholipid and β2Glycoprotein 1 (and Other Proteins)

Sohvi Horkko, Elizabeth Miller, D. Ware Branch, Wulf Palinski and Joseph L. Witztum

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.09 MB

english, 1997

41

Receptors for Oxidized Low-Density Lipoprotein on Elicited Mouse Peritoneal Macrophages Can Recognize Both the Modified Lipid Moieties and the Modified Protein Moieties: Implications with Respect to Macrophage Recognition of Apoptotic Cells

David A. Bird, Kristin L. Gillotte, Sohvi Hörkkö, Peter Friedman, Edward A. Dennis, Joseph L. Witztum and Daniel Steinberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.13 MB

english, 1999

42

Monoclonal Antibodies against Oxidized Low-Density Lipoprotein Bind to Apoptotic Cells and Inhibit Their Phagocytosis by Elicited Macrophages: Evidence That Oxidation-Specific Epitopes Mediate Macrophage Recognition

Mi-Kyung Chang, Claes Bergmark, Aino Laurila, Sohvi Hörkkö, Ki-Hoon Han, Peter Friedman, Edward A. Dennis and Joseph L. Witztum

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.47 MB

english, 1999

43

Immunization of LDL Receptor Deficient Mice With Homologous Malondialdehyde-Modified and Native LDL Reduces Progression of Atherosclerosis by Mechanisms Other Than Induction of High Titers of Antibodies to Oxidative Neoepitopes

Freigang, S., Horkko, S., Miller, E., Witztum, J. L., Palinski, W.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

1998

Language:

english

File:

PDF, 624 KB

english, 1998

44

Estrogen Replacement Therapy Increases Plasma Ghrelin Levels

Kellokoski, Eija, Pöykkö, Seppo M., Karjalainen, Anna H., Ukkola, Olavi, Heikkinen, Jorma, Kesäniemi, Y. Antero, Hörkkö, Sohvi

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2005

Language:

english

File:

PDF, 366 KB

english, 2005

45

High-fat meals induce systemic cytokine release without evidence of endotoxemia-mediated cytokine production from circulating monocytes or myeloid dendritic cells

Fogarty, Christopher L., Nieminen, Janne K., Peräneva, Lina, Lassenius, Mariann I., Ahola, Aila J., Taskinen, Marja-Riitta, Jauhiainen, Matti, Kirveskari, Juha, Pussinen, Pirkko, Hörkkö, Sohvi, Mäkine

Journal:

Acta Diabetologica

Year:

2015

Language:

english

File:

PDF, 376 KB

english, 2015

46

Plasma IgA antibody levels to malondialdehyde acetaldehyde-adducts are associated with inflammatory mediators, obesity and type 2 diabetes

Vehkala, Lauri, Ukkola, Olavi, Kesäniemi, Y. Antero, Kähönen, Mika, Nieminen, Markku S., Salomaa, Veikko, Jula, Antti, Hörkkö, Sohvi

Journal:

Annals of Medicine

Year:

2013

Language:

english

File:

PDF, 506 KB

english, 2013

47

Colorectal proliferation and apoptosis in serrated versus conventional adenoma‐carcinoma pathway: growth, progression and survival

Hörkkö, T. T., Mäkinen, M. J.

Journal:

Scandinavian Journal of Gastroenterology

Year:

2003

Language:

english

File:

PDF, 378 KB

english, 2003

48

Human monoclonal Fab and human plasma antibodies to carbamyl-epitopes cross-react with malondialdehyde-adducts

Kummu, Outi, Turunen, S. Pauliina, Prus, Piotr, Lehtimäki, Jaakko, Veneskoski, Marja, Wang, Chunguang, Hörkkö, Sohvi

Journal:

Year:

2014

Language:

english

File:

PDF, 692 KB

english, 2014

49

Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies

Tsiantoulas, Dimitrios, Perkmann, Thomas, Afonyushkin, Taras, Mangold, Andreas, Prohaska, Thomas A., Papac-Milicevic, Nikolina, Millischer, Vincent, Bartel, Caroline, Hörkkö, Sohvi, Boulanger, Chantal

Journal:

The Journal of Lipid Research

Year:

2015

Language:

english

File:

PDF, 1013 KB

english, 2015

50

Carbamyl Adducts on Low-Density Lipoprotein Induce IgG Response in LDLR −/− Mice and Bind Plasma Autoantibodies in Humans Under Enhanced Carbamylation

Kummu, Outi, Turunen, S. Pauliina, Wang, Chunguang, Lehtimäki, Jaakko, Veneskoski, Marja, Kastarinen, Helena, Koivula, Marja-Kaisa, Risteli, Juha, Kesäniemi, Y. Antero, Hörkkö, Sohvi

Journal:

Antioxidants & Redox Signaling

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013